GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs10935120 | 1 | rs1874883 | chr3:134205071 | ANAPC13 | chr3:134196547-134204865:- | 0.47 | 7.01 | 3.68E-9 | Height |
| UVM | cis | rs703842 | 1 | rs1875124 | chr12:58196802 | TSFM | chr12:58176536-58191367:+ | -0.57 | -5.04 | 5.32E-6 | Multiple sclerosis |
| UVM | cis | rs10935120 | 1 | rs1880376 | chr3:134270347 | ANAPC13 | chr3:134196547-134204865:- | -0.46 | -6.87 | 6.1E-9 | Height |
| UVM | cis | rs10935120 | 1 | rs1880377 | chr3:134270468 | ANAPC13 | chr3:134196547-134204865:- | -0.46 | -6.87 | 6.1E-9 | Height |
| UVM | cis | rs4974559 | 1 | rs1882099 | chr4:1352685 | CRIPAK | chr4:1385340-1389782:+ | 0.78 | 4.91 | 8.54E-6 | Systolic blood pressure |
| UVM | cis | rs10461617 | 1 | rs190414 | chr5:56116772 | C5orf35 | chr5:56205103-56213010:+ | 0.95 | 6.93 | 4.86E-9 | Type 2 diabetes |
| UVM | cis | rs10935120 | 1 | rs1917130 | chr3:134313773 | ANAPC13 | chr3:134196547-134204865:- | -0.45 | -6.73 | 1.03E-8 | Height |
| UVM | cis | rs2985684 | 1 | rs1952012 | chr14:50098896 | RPL36AL | chr14:50085407-50087349:- | 0.54 | 5.79 | 3.51E-7 | Carotid intima media thickness |
| UVM | cis | rs2985684 | 1 | rs1957977 | chr14:50090603 | RPL36AL | chr14:50085407-50087349:- | 0.53 | 5.65 | 5.86E-7 | Carotid intima media thickness |
| UVM | cis | rs41266839 | 1 | rs1979 | chr6:26377591 | BTN3A2 | chr6:26365398-26378546:+ | -0.86 | -4.62 | 2.34E-5 | Schizophrenia |
| UVM | cis | rs11190604 | 1 | rs2003284 | chr10:102202338 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.11 | 4.24E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs2016266 | 1 | rs2016266 | chr12:53727955 | PFDN5 | chr12:53689235-53693232:+ | 0.42 | 5.18 | 3.29E-6 | Bone mineral density;Bone mineral density (spine) |
| UVM | cis | rs2028299 | 1 | rs2028299 | chr15:90374257 | AP3S2 | chr15:90373832-90456222:- | -0.73 | -6.08 | 1.18E-7 | Type 2 diabetes |
| UVM | cis | rs9876781 | 1 | rs2045554 | chr3:48494542 | TREX1 | chr3:48501186-48509043:+ | 0.4 | 4.88 | 9.42E-6 | Longevity |
| UVM | cis | rs10935120 | 1 | rs2056603 | chr3:134312749 | ANAPC13 | chr3:134196547-134204865:- | 0.45 | 6.73 | 1.03E-8 | Height |